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7-乙基-8-二甲基三氮烯茶硷(ED MTP)为新发现的一种有效的抗癌剂。它对小鼠移植性网织细胞白血病L_(615)的生命延长率达400％以上,对其他瘤谱也有不同程度的抑制。目前正在进行临床抗肿瘤观察。为了合理选择临床试用方案,我们将临床试用的EDMTP注射液在兔体内进行了药代动力学研究。材料与方法制剂自制EDMTP注射液,批号820910,内含2％EDMTP、4％烟酰胺(助溶)和50％丙二醇(溶媒)。临用时以注射用生理盐水稀
7-Ethyl-8-Dimethyltriazene Theophylline (ED MTP) is a newly discovered potent anti-cancer agent. Its survival rate of mouse transplanted reticulocyte leukemia L_ (615) is more than 400%, and it is also inhibited to other extent. Currently undergoing clinical anti-tumor observation. In order to rationally choose clinical trials, we conducted a pharmacokinetic study of EDMTP in clinical trials in rabbits. MATERIALS AND METHODS Preparation EDMTP injection lot 820910 contains 2% EDMTP, 4% nicotinamide (solubilizing) and 50% propylene glycol (vehicle). When used to injection of saline diluted