目的:观察肌壁大部切除子宫重建术(MURU)联合曼月乐(LNG-IUS,IUS)治疗中、重度子宫腺肌病(AMS)的近期效果。方法:观察分析45例行MURU+IUS治疗的中、重度AMS患者术前和术后3个月的痛经、经量、子宫体积、CA125以及IUS位置。结果:术前患者痛经评分、经量评分、CA125、子宫体积分别为:(6.31±3.33)分、(4.15±0.44)分、(76.51±44.62)U/ml、(273.73±109.69)cm3,术后3个月以上指标分别为:0.00分、(0.70±0.60)分、(10.12±4.03)U/ml、(58.80±23.17)cm3(P<0.01);IUS无脱落、嵌顿或异位发生。结论:MURU联合IUS治疗中、重度AMS的近期疗效非常显著,无并发症发生,值得进一步观察研究。 Objective: To observe the short-term effect of MURU combined with LNG-IUS in the treatment of moderate and severe adenomyosis (AMS). Methods: Forty-five patients with moderate and severe AMS treated with MURU + IUS were observed for dysmenorrhea, menstrual flow, uterine volume, CA125 and IUS position before and 3 months after operation. Results: The scores of dysmenorrhea, menstrual flow, CA125 and uterine volume were (6.31 ± 3.33) points, (4.15 ± 0.44) points, (76.51 ± 44.62) U / ml and (273.73 ± 109.69) cm3 respectively After 3 months, the indexes were 0.00, 0.70 ± 0.60, (10.12 ± 4.03) U / ml, (58.80 ± 23.17) cm3 respectively (P <0.01); IUS had no shedding, incarcerated or ectopic . Conclusions: The short-term curative effect of moderate and severe AMS in MURU combined with IUS is very significant and no complication occurs. It is worth further investigation.