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1955年Cronkhite 与Canada 二氏报告2例伴随皮肤色素沉着、脱毛、指(趾)甲萎缩、无遗传因素的广泛消化道息肉病人后,相继又有同样病例报告。1966年
In 1955, Cronkhite and Canada II reported two cases of polyposis patients with skin pigmentation, hair removal, atrophy of the nails, and no hereditary factors. 1966