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目的探讨具有分泌性激素功能的卵巢肿瘤的临床特征与内分泌症状,为正确诊断提供临床参考资料。方法回顾性分析1980年1月至2003年1月在北京协和医院就诊的具有分泌性激素功能的卵巢肿瘤50例,分别对症状、肿瘤种类、性激素等相互间关系进行统计学分析。结果50例中以卵巢颗粒细胞瘤为多见,其次为卵巢支持间质细胞瘤等。主要为雄激素与雌激素增多症状,其中雄激素异常的常见临床表现依次为多毛、阴蒂增大与喉结出现。多毛为首发表现,多见于卵巢支持间质细胞瘤与卵巢类脂质细胞瘤。雌激素异常的主要临床表现为绝经后出血与月经紊乱,多见于颗粒细胞瘤。结论多毛、阴蒂增大等是雄激素过多的最常见表现,睾酮≥6.0nmol/L者应高度怀疑发生肿瘤的可能,治疗以手术为主。
Objective To investigate the clinical features and endocrine symptoms of ovarian tumors with secretory hormone function and provide clinical reference materials for correct diagnosis. Methods A retrospective analysis of 50 cases of ovarian tumors with secretory hormone function treated in Peking Union Medical College Hospital from January 1980 to January 2003 was performed. The relationship among symptoms, tumor types, sex hormones and so on were statistically analyzed. Results 50 cases of ovarian granulosa cell tumor is more common, followed by ovarian support for stromal cell tumors. Mainly for the androgen and estrogen increased symptoms, including the common clinical manifestations of androgen abnormalities followed by hirsutism, clitoris and Adam’s apple appear. Hairy hair as the first performance, more common in the ovary support stromal cell tumor and ovarian lipid cell tumor. The main clinical manifestations of estrogen abnormalities are postmenopausal bleeding and menstrual disorders, more common in granulosa cell tumor. Conclusion Hirsutism and clitoral enlargement are the most common manifestations of hyperandrogenism. Testosterone ≥6.0nmol / L should be highly suspected of the possibility of tumor, the treatment of surgery-based.