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利多卡因最初合成于1943年,多年来被用作局部麻醉剂。1950年首次报道作为抗心律失常药物。1963年它成功地被用于治疗心脏手术时以及术后发生的心律失常。从此,利多卡因被广泛地应用于治疗室性心律失常,且成为治疗和预防急性心肌梗塞后心律失常的最广泛应用的药物。
Lidocaine was first synthesized in 1943 and has been used as a local anesthetic for many years. First reported in 1950 as an anti-arrhythmic drug. It was successfully used in 1963 to treat arrhythmias during and after heart surgery. Since then, lidocaine has been widely used in the treatment of ventricular arrhythmias and has become the most widely used drug for the treatment and prevention of arrhythmias after acute myocardial infarction.