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生物化学特征肝素是一种聚葡糖胺糖醛酸(glycosami-noglycuron),广泛地分布在动物组织中。它是由2-氨基-2去氧己糖和己糖醛酸交替组成,通常附着在蛋白质的主链上。由于氨基己糖上有 N-硫酸基,在糖醛酸上有 O-硫酸基团,因而使肝素带强大的阴电荷,从而具备了抗凝活性所必需的结构特征。肝素分子量为4,000～30,000,商品肝素分子量为4,000～16,000,用等电聚焦电泳目前已确定肝素具有21种成分。正常人体的肝素平均半寿期是90(30～360)min。半寿期是剂最依赖性的,静脉注射3,000U 时半寿期是
Biochemical characteristics Heparin is a glycosaminoglyccuron widely distributed in animal tissues. It consists of alternating 2-amino-2 desoxyhexoses and hexuronic acid, usually attached to the protein’s backbone. Since hexosaminoglycans have an N-sulfate group and uronic acid has an O-sulfate group, heparin carries a strong negative charge and thus has the structural features necessary for anticoagulant activity. Heparin has a molecular weight of 4,000 to 30,000 and commercial heparin has a molecular weight of 4,000 to 16,000. It has been confirmed by isoelectric focusing that heparin has 21 components. Normal human heparin average half-life of 90 (30 ~ 360) min. Half-life is the most dependent agent, with a half-life of 3,000 U.