论文部分内容阅读
目的探讨家族性甲状腺非髓样癌(familial non-medullary thyroid cancer,FNMTC)的最优筛查年龄。方法对武清区人民医院最近20余年甲状腺癌患者亲属筛查数据进行分析,筛选出FNMTC家族并对其随访数据进行分析,从而得出家族性甲状腺非髓样癌的最优筛查年龄。结果在筛查随访期间FNMTC患者亲属发现甲状腺存在≥5 mm结节为44.4%(15例),出现在患者子一代中的为19.2%,出现在患者亲代中的为90.0%。发现甲状腺结节的最小年龄为10岁,发现甲状腺癌最小年龄为18岁。在筛查随访期间超声发现甲状腺结节微钙化与甲状腺癌高度相关。成员亲属诊断为甲状腺癌的筛查随访过程中,诊断甲状腺癌的年龄越小,则发生甲状腺外侵犯的可能性越低。结论 FNMTC患者>10岁的一级血亲(包括患者亲代亲属)应进行甲状腺超声的筛查和随访,有助于早期诊断甲状腺癌。
Objective To investigate the optimal screening age of familial non-medullary thyroid cancer (FNMTC). Methods We analyzed the screening data of relatives of patients with thyroid cancer in Wuqing District People’s Hospital for more than 20 years, screened out the FNMTC family and analyzed their follow-up data to get the optimal screening age of familial thyroid non-myeloid carcinoma. Results Relatives of FNMTC patients during screening follow-up found 44.5% (15 cases) of ≥5 mm nodules in the thyroid gland, 19.2% in the patient’s first generation, and 90.0% in the patient’s parent. The minimum thyroid nodule age was found to be 10 years and the minimum thyroid cancer age was found to be 18 years. Thyroid nodule micro-calcification was found to be highly correlated with thyroid cancer during ultrasound follow-up. Members of the relatives diagnosed as thyroid cancer screening follow-up process, the diagnosis of thyroid cancer, the younger, then the possibility of extra-thyroid invasion is less likely. Conclusions Screening and follow-up of thyroid ultrasound should be carried out in first-degree relatives of FNMTC patients> 10 years old (including the relatives of the patients), which is helpful for the early diagnosis of thyroid cancer.