本文介绍药物代谢动力学(Pharmacokinetics简称药代动力学)原理在长效制剂、制剂的生物利用度(Bioavailability)研究工作中的运用问题。生物利用度是药剂间相对疗效的一种度量。在长效制剂中,既有生物利用度问题,又有自己独特的设计原理问题,都可以运用药代动力学方法加以研究。制剂生物利用度的详细情况,可以参考有关文献。它虽不是本文讨论的重点,但为了说明问题,拟作简述如下。 This article describes the pharmacokinetic (Pharmacokinetics referred to pharmacokinetic) principle in the long-acting formulations, formulations, bioavailability (Bioavailability) in the application of the work. Bioavailability is a measure of the relative efficacy of pharmaceuticals. In the long-acting preparation, both the bioavailability problem, but also has its own unique design principles, can be applied pharmacokinetic methods to be studied. Preparation of bioavailability of the details, you can refer to the relevant literature. Although it is not the focus of this article, in order to illustrate the problem, it is intended to briefly describe as follows.