Goedde等人发现,所有高加索人的肝脏内均有2种主要的醛脱氢酶,而几乎50%的东方人则只有ALDH_1(胞浆异构酶)但无ALDH_2(线粒体异构酶)。后来Teng进一步证实了这一点并认为,东方人对酒精敏感的高发率可能与其中许多人缺少ALDH_2有关。这是首次提出ALDH_2缺失可能系基因缺失之故。由于肝活检标本难得,进行家族性ALDH类型分析又极不容易,Goedde等人1980年提出用头发根提取物做等电聚焦法分析以检测ALDH表型。鉴于 Goedde et al. Found that there are 2 major aldehyde dehydrogenases in all Caucasians’ livers, while ALDH1 (cytosolic isomerase) but ALDH2 (mitochondrial isomerase) are present in almost 50% of the Asians. Teng later confirmed this further and argued that the high rate of alcohol-sensitive Asians may be related to the lack of ALDH2 in many of them. This is the first time that ALDH_2 deletion may be caused by deletion of the gene. Because of rare liver biopsy specimens, familial ALDH type analysis is extremely difficult, Goedde et al. Proposed in 1980 using hair root extract isoelectric focusing analysis to detect ALDH phenotype. Given that