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以注射糖皮质激素、雌激素、利血平和强迫游泳实验为基本依据,从动物模型的外观表征、生化机制等方面探讨抑郁症与中医阳虚证之间的关系。发现抑郁症与阳虚证之间存在诸多相似之处,许多补肝肾、助阳气的药物具有良好的抗抑郁作用。从而推测抑郁症的中医病机以肝肾阳虚为基础,利用抑郁症的动物模型、病理机制有助于中医肝肾阳虚证的证候本质研究。
Based on the experiments of injection of glucocorticoid, estrogen, reserpine and forced swimming, the relationship between depression and yang deficiency syndrome was explored from the appearance and biochemical mechanism of the animal model. Found that there are many similarities between depression and yang deficiency syndrome, many liver and kidney, yang help drugs have a good antidepressant effect. Therefore, it is speculated that the TCM pathogenesis of depression is based on liver-kidney yang deficiency and the use of the animal model of depression and pathological mechanism contribute to the study of syndrome essence of liver-kidney-yang deficiency syndrome.