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[目的]观察补肾清利活血汤联合奥美沙坦酯治疗慢性肾小球肾炎疗效。[方法]使用随机平行对照方法,将96例住院患者按掷骰子法简单随机分为两组。控制蛋白质摄入及高脂饮食,水肿用利尿剂,避免继发感染。对照组48例奥美沙坦酯,20mg/次,1次/2d。治疗组48例补肾清利活血汤(山药~炒12g,牡丹皮10g,熟地黄、怀牛膝各15g,山萸肉、茯苓各12g,白花蛇舌草30g,生晒参12g,桃仁10g,陈皮6g,甘草、焦白术各10g,丹参24g,黄芪30g,半枝莲、蒲公英各15g,白茅根30g,红花10g,川芎、大小蓟各15g;肾阴虚加麦冬、龟板;阳虚加巴戟天、仙灵脾;腰痛加续断、杜仲),1剂/d,水煎400mL,早晚饭前口服;西药治疗同对照组。连续治疗21d为1疗程。观测临床症状、尿蛋白、Scr、血尿、不良反应。连续治疗3疗程,判定疗效。[结果]治疗组痊愈20例,显效15例,有效10例,无效3例,总有效率96.32%。对照组痊愈16例,显效16例,有效5例,无效11例,总有效率77.08%。治疗组疗效优于对照组(P<0.05)。尿蛋白两组均有改善(P<0.05),Scr无改善(P>0.05),血尿人数治疗组降低显著(P<0.05),对照组降低不显著(P>0.05),尿蛋白、血尿人数治疗组改善优于对照组(P<0.05),Scr两组无显著差异(P>0.05)。[结论]补肾清利活血汤联合奥美沙坦酯治疗慢性肾小球肾炎疗效满意,无严重不良反应,值得推广。
[Objective] To observe the curative effect of Bushen Qinglihuoxue Decoction combined with olmesartan medoxomil on chronic glomerulonephritis. [Method] Using randomized parallel control method, 96 inpatients were randomly divided into two groups according to the method of dice rolling. Control protein intake and high-fat diet, edema with diuretics, to avoid secondary infection. The control group, 48 cases of olmesartan, 20mg / time, 1 / 2d. In the treatment group, 48 cases of Bushen Qingliuhuoxue Decoction (yam ~ scrambled 12g, Cortex Moutan 10g, Rehmannia glutinosa, Achyranthes bidentata each 15g, cornus, Poria Bark 12g, Hedyotis diffusa 30g, raw sunburn 12g, peach kernel 10g, Dried tangerine peel, dried tangerine peel, dried tangerine peel, dried tangerine peel, dried tangerine peel, dried tangerine peel, dried tangerine peel, dried tangerine peel, Plus Morinda officinalis, Epimedium; low back pain plus continued broken, Eucommia), 1 / d, decoction 400mL, sooner or later meals before oral administration; western medicine treatment with the control group. Continuous treatment of 21d for a course of treatment. Clinical symptoms, urinary protein, Scr, hematuria, adverse reactions were observed. Continuous treatment of 3 courses to determine the efficacy. [Results] The treatment group cured 20 cases, markedly effective in 15 cases, effective in 10 cases, 3 cases, the total effective rate was 96.32%. Control group cured 16 cases, 16 cases markedly effective in 5 cases, ineffective in 11 cases, the total effective rate was 77.08%. The treatment group was better than the control group (P <0.05). (P <0.05). The number of hematuria decreased significantly in the treatment group (P <0.05), while the control group showed no significant reduction (P> 0.05). The urinary protein, the number of hematuria Treatment group improved better than the control group (P <0.05), Scr two groups no significant difference (P> 0.05). [Conclusion] Bushe Qingliuhuoxue Decoction combined with olmesartan medoxomil in the treatment of chronic glomerulonephritis has satisfactory curative effect and no serious adverse reactions, which deserves promotion.