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利用抗生物素-生物素-过氧化酶复合物技术检查正常鼻粘膜、鼻息肉、鼻内翻性乳头状瘤和鼻乳头状腺癌中的花生凝集素、刀豆凝集素、荆豆凝集体、槐凝集素、麦胚凝集素、豌豆凝集素的受体及癌胚抗原和角蛋白的改变,提示:(1)花生凝集素受体和荆豆凝集素受体在鼻粘膜中的分布与其分化、增生、转化和恶变程度有关:(2)刀豆凝集素受体在鼻粘膜中的分布随其转化和恶变程度增加而增多;(3)同一细胞膜表面可存在有多种凝集索受体:(4)凝集素组织化学检查法较免疫组织化学检查法更具经济、方便、迅速、灵敏的特点。因此,可以利用凝集素来检查鼻部肿瘤的分化、增生、转化和恶变程度,为临床诊断、治疗和预后提供客观指标。
Detection of Peanut Agglutinin, Jack Bean Agglutinin, and Jingdou Aggregate in Normal Nasal Mucosa, Nasal Polyps, Inverted Papilloma, and Nasomal Papillary Adenocarcinoma Using Avidin-biotin Peroxidase Complex Technique Changes in the receptors of lectin, lectin, wheat germ agglutinin, pea lectin, and carcinoembryonic antigen and keratin suggest that: (1) Distribution of peanut agglutinin receptor and vinegar lectin receptor in nasal mucosa and its The degree of differentiation, proliferation, transformation and malignancy are related to: (2) The distribution of the lectin receptors in the nasal mucosa increases with the degree of transformation and malignancy; (3) Multiple lectin receptors may be present on the same cell membrane surface : (4) Lectin histochemical examination is more economical, convenient, rapid, and sensitive than immunohistochemistry. Therefore, lectins can be used to examine the degree of differentiation, proliferation, transformation, and malignancy of nasal tumors, providing objective indicators for clinical diagnosis, treatment, and prognosis.