对胃蛋白酶原(pepsinogen,简称PG)的研究,历史虽已很久,但近年因发现其亚群并建立了新的检测方法而又引起重视.据报道,血清胃蛋白酶原(SPG)I含量能反映胃的分泌机能;对诊断肠腺化生有特异性;SPGI明显降低则预示肠型胃癌的危险性增加.此外,胃蛋白酶原表型与胃癌、十二指肠溃疡的遗传性亦有关系.为此,本文就近年来胃蛋白酶原与胃病关系方面的研究概况作一简要综述. Although the history of pepsinogen (PG for short) has been studied for a long time, it has attracted attention in recent years due to the discovery of its subgroups and the establishment of new detection methods. It has been reported that serum pepsinogen (SPG) I levels can be Reflects the secretory function of the stomach; specific for the diagnosis of intestinal metaplasia; a significant decrease in SPGI is indicative of an increased risk of intestinal type gastric cancer. In addition, the pepsinogen phenotype is also associated with the heritability of gastric and duodenal ulcers. For this reason, this article gives a brief review of recent research on the relationship between pepsinogen and stomach diseases.