Triclosan,a kind of multi-purpose biocide,was widely used household cleaning and personal care products.The widespread use of triclosan has potential risk to the ecotype and human health due to its release into sediment,surface and ground water resources.A molecularly imprinted electrochemical sensor for triclosan detection in cosmetic emulsion was synthesized and characterized.In order to determine the suitable monomer and evaluate the template-monomer geometry as well as the interaction energy in the template-monomer prepolymerization mixture,a computational study was applied.We found that the complex formed by hybrid monomers (triclosan(o-phenylenediamine-co-resorcinol)) had more hydrogen bonds and larger binding energy than that by single kind of monomers (triclosan(o-phenylenediamine)2 and triclosan(resorcinol)2).Therefore,hybrid monomers were used to synthesize the imprinted electrochemical sensor,which exhibits a high sensitivity and selectivity for triclosan sensing with the detection range 0～ 15 ng· mL-1 and detection limit 0.41 ng· mL-1.