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目的 2型糖尿病(T2DM)患者血糖变异性水平与认知功能的相关性。方法选取河南省人民医院住院的T2DM患者100例为研究对象,据结果分两组:2型糖尿病伴认知功能障碍者60例,男35例,女25例,为试验组;2型糖尿病伴认知功能正常者40例,男20例,女20例,为对照组。入院后均行72小时动态血糖监测(CGM),计算动态血糖波动指标,并根据认知功能量表(RBANS量表)结果评价认知功能评分,收集其人口学资料及临床检验指标,比较两组间各项动态血糖指标、认知功能量表评分及各项临床生化指标,组间比较采用t检验或秩和检验,相关性分析采用Pearson相关或Spearman相关分析,多因素相关分析采用偏相关分析,P<0.05为差异有统计学意义。结果 (1)与对照组的MAGE、MPPGE、MODD[(4.8±1.3)、(4.5±1.4)、(2.4±0.8)]相比,试验组分别为[(7.0±2.6)、(6.4±1.9)、(3.1±1.3)],均显著增加,差异均有统计学意义(t=4.887,5.321,2.856,P<0.05)。(2)MPPGE、MODD与RBANS量表延迟记忆(r偏=0.252,r偏=0.225,P<0.05)评分和总分(r偏=0.258,r偏=0.272,P<0.05)呈正相关。结论 T2DM伴认知功能障碍者血糖变异性明显增大,血糖波动幅度与其认知功能评分呈正相关,提示血糖变异性可能影响认知功能受损的发生发展。
Objective To investigate the correlation between the level of plasma glucose and cognitive function in type 2 diabetes mellitus (T2DM). Methods 100 cases of T2DM patients hospitalized in People’s Hospital of Henan Province were selected as the research object. According to the results, there were two groups: 60 cases of type 2 diabetes with cognitive impairment, 35 males and 25 females, which were the experimental group; type 2 diabetes mellitus 40 cases of normal cognitive function, 20 males and 20 females, as the control group. 72 hours after admission underwent continuous glucose monitoring (CGM), calculated indicators of glucose fluctuations, and according to cognitive function scale (RBANS scale) the results of the evaluation of cognitive function score, collect demographic data and clinical laboratory indicators, comparing two the dynamic glycemic index groups, cognitive function scale score and the clinical biochemical parameters between groups were compared using the t test or rank sum test, correlation analysis using Pearson correlation or Spearman correlation analysis, multivariate analysis using partial correlation Analysis, P <0.05 for the difference was statistically significant. Results (1) Compared with control group, MAGE, MPPGE, MODD [(4.8 ± 1.3), (4.5 ± 1.4), (2.4 ± 0.8) ), (3.1 ± 1.3)], both of which were significantly increased (t = 4.887,5.321,2.856, P <0.05). (2) There was a positive correlation between MPPGE, MODD and RBANS scales (r = 0.252, r = 0.225, P <0.05) and total score (r = 0.258, r = 0.272, P <0.05). Conclusion The T2DM patients with cognitive impairment have significantly increased blood glucose variability, and the amplitude of blood glucose is positively correlated with their cognitive function scores, suggesting that the blood glucose variability may affect the occurrence and development of cognitive impairment.