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目的探讨肺结核(TB)合并真菌感染患者的易患因素、临床特点及常见菌种,提高对肺部真菌感染的认识,以便更有力地诊治和预防该疾病的发生,减少患者的病死率。方法回顾性分析2005年1月~2006年12月河北省邯郸市传染病医院收治的80例TB合并真菌感染患者的病例资料,观察TB继发真菌感染的临床特点、常见菌种及治疗方法。结果 TB合并真菌感染以复治及合并基础慢性疾病的老年患者为主,其分别占72.5%和62.5%;检出病原菌以白色念珠菌为主(90.0%);主要采用HRZE(S)方案联合抗真菌治疗。结论 TB合并真菌感染早期进行及时规范治疗,效果较明显,临床医师应提高对TB合并真菌感染的认识,早诊断、早治疗是减少肺部真菌感染发生的关键。
Objective To explore the predisposing factors, clinical features and common bacterial species in patients with pulmonary tuberculosis (TB) complicated with fungal infection and to improve the understanding of pulmonary fungal infection in order to more effectively diagnose and prevent the occurrence of the disease and reduce the case fatality rate. Methods A retrospective analysis of 80 cases of TB complicated with fungal infection admitted to Handan Infectious Disease Hospital of Hebei Province from January 2005 to December 2006 was conducted to observe the clinical features, common bacteria and treatment methods of TB secondary fungal infection. Results The majority of elderly patients with retreatment and combination of chronic fungal diseases accounted for 72.5% and 62.5%, respectively. Candida albicans was the main pathogen (90.0%). HRZE (S) Anti-fungal treatment. Conclusion TB complicated with fungal infection early standardized treatment, the effect is more obvious, clinicians should improve understanding of TB combined with fungal infection, early diagnosis and early treatment is to reduce the occurrence of pulmonary fungal infection is the key.