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von Hippel 于1888年设计了角膜移植器械,为近一世纪以来角膜移植的发展开辟了道路。Zirm 1906年第一次成功地作成了穿透角膜移植。以后,Elschnig 做了大量角膜移植手术,在1930年以前该氏共作179例穿透移植术,其中39例透明愈合,在抗菌素与激素尚未问世的时代,其成绩是卓著的。接着,美国的 Castroviejo(1932.1934)和英国的 Thomas(1933.1934)、法国的 Paufique(1946)又进一步发展了角膜移植术,后者并特别强调板层移植术的价值。1954年,Leigh 提出简化操作技术为板层和穿透移植术成功的要点。
Von Hippel designed a corneal transplant in 1888 that opened the way for the development of corneal transplantation in the last century. For the first time in 1906, Zirm made penetrating keratoplasty. Since then, Elschnig has done a lot of corneal transplants. Before 1930, the cohort made 179 penetrating transplants and 39 of them were healed transparently. Their achievements were outstanding in the days when antibiotics and hormones had not yet come out. Subsequently, Castroviejo (1932.1934) in the United States, Thomas (1933.1934) in the United Kingdom, and Paufique (1946) in France further developed corneal transplantation, with the latter emphasizing the value of lamellar grafting. In 1954 Leigh proposed the key points to simplify the operation of the technique for the success of plies and penetrating grafts.