国内外关于铅中毒的早期诊断,研究有四方面。(1)临床上寻找特异的早期体征;(2)生物标本中直接测定铅的含量;(3)检查铅对机体卟啉代谢产物和酶的影响;(4)组织和形态学上观察异常红细胞的数量。本文从临床方面寻找可作参考指标着手,从1978年11月开始至今,对37名从事铅作业的挂瓦工进行普查,发现有十七名眼底有改变, At home and abroad on the early diagnosis of lead poisoning, there are four aspects. (1) clinical specific early signs; (2) the direct determination of lead in biological specimens; (3) the impact of lead on the metabolism of porphyrin metabolites and enzymes; (4) histological and morphological observation of abnormal red blood cells quantity. This article from the clinical aspects can be used as a reference index to start from November 1978 so far, 37 workers engaged in the plumbing of plumbers survey found that there are 17 eyes have changed,