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目的:研究左氧氟沙星的PK/PD参数与临床及细菌学疗效的关系。方法:选取符合研究条件的下呼吸道感染患者49例,给予左氧氟沙星500mg·d~(-1)静脉点滴治疗。治疗前后留取痰标本进行细菌培养,应用E-test方法进行MIC测定。应用高效液相色谱法进行血药浓度的测定。观察并记录临床疗效、细菌学疗效和不良反应的发生情况。结果:临床有效率为71.43%(35/49),细菌学有效率为57.14%(28/49)。肌酐清除率是影响PK最主要因素。结论:C_(max)/MIC和AUIC与临床和细菌学疗效有非常显著的关系,且两参数有较好的相关性(r=0.9211),但AUIC与疗效更为密切。
Objective: To study the relationship between PK / PD parameters of levofloxacin and clinical and bacteriological efficacy. Methods: Forty-nine patients with lower respiratory tract infection who were eligible for the study were enrolled in this study. 500 mg · d -1 of levofloxacin was given intravenously. Sputum samples were collected before and after treatment for bacterial culture, the application of E-test method MIC determination. Determination of plasma concentration using high performance liquid chromatography. Observe and record the clinical efficacy, bacteriological efficacy and adverse reactions. Results: The clinical effective rate was 71.43% (35/49). The bacteriological efficiency was 57.14% (28/49). Creatinine clearance is the most important factor affecting PK. CONCLUSION: C max / MIC and AUIC have a very significant relationship with clinical and bacteriological efficacy, and the two parameters have a good correlation (r = 0.9211). However, AUIC is more closely related to efficacy.