概述自从20年前Goodman等临床开始药物治疗肿瘤以来,药物在造血系统及胃肠道所引起的中毒作用,成为治疗中的极大限制。Kloop等(1950)首倡肿瘤区动脉灌注抗癌药物法(毒性反应较静脉注射为低,且疗效亦较好),并认为此法可做为放射治疗的一种辅助治疗。Creech等于1957年6月首 Overview Since the beginning of drug treatment of tumors by Goodman et al. 20 years ago, the toxic effects of drugs in the hematopoietic system and the gastrointestinal tract have become extremely limited in therapy. Kloop et al. (1950) advocated arterial infusion of anti-cancer drugs in the tumor area (the toxicity was lower than intravenous injection, and the efficacy was also good), and it was considered that this method could be used as an adjuvant therapy for radiation therapy. Creech equals June 1957