论文部分内容阅读
目的 研究苏州地区汉族人胶原受体α2 基因编码序列中与血小板表面α2 β1 的表达相关的C80 7T基因多态性特点。方法 应用PCR技术结合BglⅡ和AseⅠ酶切分析、聚丙烯酰胺凝胶电泳、溴乙锭染色及DNA测序分析 ,研究了苏州地区 110名汉族人α2 基因编码序列C80 7T基因多态性特点。结果 苏州地区汉族人等位基因T80 7与等位基因C80 7的频率分别为 0 .2 91和 0 .70 9,总理论杂合率为 41%。等位基因 80 7T T纯合子、等位基因 80 7C T杂合子和等位基因 80 7C C纯合子的频率分别为0 0 18,0 .5 46和 0 .436。结论 苏州地区汉族人α2 基因的C80 7T基因多态性与其他人种差异显著
Objective To investigate the polymorphism of C80 7T gene associated with the expression of α2β1 on platelet surface in the α2 gene coding sequence of collagen receptor of Han Chinese in Suzhou area. Methods Polymorphisms of the C80 7T gene of α2 gene in 110 Chinese Han population in Suzhou were studied by PCR, combined with restriction endonuclease analysis of Bgl Ⅱ and Ase Ⅰ, polyacrylamide gel electrophoresis, ethidium bromide staining and DNA sequencing. Results The frequencies of allele T80 7 and allele C80 7 in Han nationality in Suzhou area were 0.21 and 0.709 respectively, and the overall theoretical heterozygosity was 41%. The frequencies of alleles 80 7T T homozygote, alleles 80 7C T heterozygote and alleles 80 7C C homozygotes were 0 0 18, 0 .5 46 and 0 .436, respectively. Conclusion The polymorphism of C80 7T gene of α2 gene in Suzhou Han population was significantly different from other races