目的 :探讨早期测定血清肿瘤坏死因子 (TNF)水平能否判定疾病的严重程度。方法 :观察 77例急性胰腺炎患者早期血清TNF水平 ,并与C反应蛋白 (CRP)作比较。结果 :血清TNF水平超过可探测范围者只有 7例 ( 9% ) ,但有 18例出现并发症( 2 3% ) ;以TNF水平预测疾病严重程度的敏感性为 16 % ,准确率为 74 % ,而CRP则分别为 84 %、74 %。结论 :与CRP比较 ,早期测定血清TNF水平对评价疾病严重程度并无很大的临床意义。 Objective: To investigate whether the early determination of serum tumor necrosis factor (TNF) levels can determine the severity of the disease. Methods: The early serum TNF levels in 77 patients with acute pancreatitis were observed and compared with C-reactive protein (CRP). RESULTS: Only 7 patients (9%) had serum TNF levels beyond the detectable range, but 18 patients had complications (23%). The predictive disease severity with TNF level was 16% and the accuracy rate was 74% , While the CRP was 84%, 74%. CONCLUSIONS: Compared with CRP, the early determination of serum TNF level has no significant clinical value in evaluating the severity of the disease.