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已知各种恶性肿瘤患者有血液凝固系统激活增强现象,可能系肿瘤细胞分泌前凝血质活力的结果.Sakuragawa发现人体肿瘤组织存有Ⅶ因子,Pineo证实粘液浸出物中含有糖蛋白,能直接激活X因子,后Gordon另一类型的Ⅶ因子,称之为恶性肿瘤中的X因子激活活力(FXAA),也是癌前凝血质A(CPA).Gordon在人类结肠癌中找出CPA,但未能阐明前凝血质活力与恶性肿瘤分化程度之间的关系.作者研究的目的在于解决这一问题.研究方法:收集50例结、直肠癌和4例非肠道癌肿的切除标本,取其存活的癌肿组织,研碎后制成
It is known that patients with various malignancies have enhanced blood coagulation system activation and may be the result of precancerous activity secreted by tumor cells. Sakuragawa found that VII factor is present in human tumor tissues. Pineo confirmed that glycoproteins are contained in mucus extracts and can be activated directly. Factor X, followed by Gordon, another type of factor VII, is called X-factor activating activity (FXAA) in malignant tumors, and also precancerous coagulation A (CPA). Gordon found CPA in human colon cancer, but failed to Clarify the relationship between precoagulant activity and the degree of malignancy. The purpose of the author’s research is to solve this problem. Research method: Collect resection specimens of 50 cases of colorectal cancer and 4 cases of non-intestinal cancer and take it for survival. Cancer tissue, made by grinding