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[目的]观察扶正化瘀胶囊对丙型肝炎失代偿期肝硬化患者免疫调节以及抗纤维化作用。[方法]收集2013年8月~2015年8月我院消化内科收治的丙型肝炎失代偿期肝硬化患者84例,使用数字法随机分为常规治疗对照组和扶正化瘀胶囊治疗组,每组42例。比较2组治疗前后IL-17、IL-23、HA、LN、PCⅢ、CⅣ和Child-Pugh评分的变化。[结果]治疗前2组IL-17、IL-23、HA、LN、PCⅢ、CⅣ和Child-Pugh评分差异无统计学意义(P>0.05),治疗后2组上述指标均出现显著减低(P<0.05和P<0.01),但观察组对IL-17(18.42±4.13ng/ml25.73±5.16ng/ml)、IL-23(13.28±3.76ng/ml21.53±5.21ng/ml)、HA(129.22±30.65ng/ml197.7±41.32ng/ml)、LN(102.47±14.82ng/ml138.92±21.63ng/ml)、PCⅢ(112.54±19.82ng/ml152.1±28.67ng/ml)、CⅣ(122.14±20.12ng/ml157.55±26.86ng/ml)和Child-Pugh(6.25±1.26ng/ml7.32±1.25ng/ml)评分的减低作用显著优于对照组(P<0.05)。[结论]扶正化瘀胶囊可以减低丙肝失代偿期肝硬化患者IL-23和IL-17因子表达,发挥抗纤维化作用,显著减低Child-Pugh评分,有利于丙肝失代偿期肝硬化患者肝功能的恢复。
[Objective] To observe the effect of Fuzheng Huayu capsule on immune regulation and anti-fibrosis in patients with decompensated cirrhosis of hepatitis C [Methods] Eighty-four patients with hepatitis C decompensated cirrhosis admitted from August 2013 to August 2015 in our hospital were randomly divided into routine treatment control group and Fuzhenghuayu capsule treatment group, 42 cases in each group. The changes of IL-17, IL-23, HA, LN, PCⅢ, CⅣ and Child-Pugh scores before and after treatment were compared between the two groups. [Results] There was no significant difference in the scores of IL-17, IL-23, HA, LN, PCⅢ, CⅣ and Child-Pugh between the two groups before treatment (P> 0.05) (18.42 ± 4.13ng / ml25.73 ± 5.16ng / ml), IL-23 (13.28 ± 3.76ng / ml21.53 ± 5.21ng / ml), IL-17 (129.22 ± 30.65ng / ml197.7 ± 41.32ng / ml), LN (102.47 ± 14.82ng / ml138.92 ± 21.63ng / ml), PCⅢ (112.54 ± 19.82ng / ml152.1 ± 28.67ng / ml) (122.14 ± 20.12ng / ml157.55 ± 26.86ng / ml) and Child-Pugh (6.25 ± 1.26ng / ml7.32 ± 1.25ng / ml) were significantly lower than those of the control group (P <0.05) . [Conclusion] Fuzhenghuayu Capsule can reduce the expression of IL-23 and IL-17 in patients with decompensated hepatitis C, play an anti-fibrosis effect, significantly reduce the Child-Pugh score, which is in favor of patients with decompensated liver cirrhosis Recovery of liver function.