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目的 :了解流行性出血热病毒 ( EHFV)对肝脏的损害及肝功能的影响。方法 :对 5 6例流行性出血热( EHF)患者的肝功能及乙型肝炎病毒 ( HBV )标记物的检测结果进行分析。结果 :14 9例 ( 88% )出现 AL T和 AST升高 ,其中有 2 3例 ( 4 1% )伴有血清总胆红素 ( STB)升高 ;2 2 6例重型和危重型病人中 ,发生重度肝损害 10例 ,占全部重度肝损害的 83 %。 3 5 1例进行 HBV标记物检测 ,发现 HBV感染 2 4例 ,EHFV重叠 HBV感染率为 4 7% ;单纯感染组与重叠感染组的肝损害情况比较 ,重叠感染组的 AL T比单纯感染组显著升高 ( P<0 .0 5 ) ,而两组的肝损害发生率和 STB均值均无显著性差异 ( P>0 .0 5 )。结论 :1EHF并发肝损害较普遍 ,病情重者发生肝损害的程度也严重 ;2 EHF重叠 HBV感染也较多见 ,但重叠 HBV感染者中的肝损害的发生率及黄疸的程度并无明显升高。
Objective: To understand the impact of epidemic hemorrhagic fever virus (EHFV) on liver damage and liver function. Methods: The liver function and hepatitis B virus (HBV) markers in 56 cases of epidemic hemorrhagic fever (EHF) were analyzed. RESULTS: Twenty-nine (88%) patients had elevated ALT and AST, of which 23 (41%) had elevated serum total bilirubin (STB). Of 226 patients with severe and sub-critical type , Severe liver damage occurred in 10 cases, accounting for 83% of all severe liver damage. 351 cases of HBV markers detected and found 24 cases of HBV infection, EHFV overlap HBV infection rate was 47%; simple infection group and overlapping infection group of liver damage compared to overlapping infection ALT than simple infection group (P <0.05). There was no significant difference in the incidence of liver damage and STB between the two groups (P> 0.05). Conclusions: 1EHF complicated by liver damage is more common, severe cases of severe liver damage are also serious; 2 EHF overlap HBV infection is more common, but overlap HBV infection in the incidence of liver damage and jaundice levels did not significantly high.