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目的探讨胆管癌全基因组DNA拷贝数的变化特征,寻找与胆管癌相关的癌基因和抑癌基因的染色体候选区域。方法采用比较基因组杂交方法分析18例胆管癌组织基因组的不平衡,即DNA拷贝数的扩增和丢失。结果胆管癌常见的染色体DNA扩增区域是8q、20q、5p、17q;染色体DNA缺失区域为3p、18q、17p、8p、9p。结论胆管癌中存在多条染色体拷贝数的改变,3p、5p、8p、8q、9p、17p、17q、18q、20q等部位可能分别存在与胆管癌密切相关的癌基因和抑癌基因。
Objective To investigate the changes of copy number of whole genome DNA in cholangiocarcinoma and to search for chromosomal candidate regions of oncogenes and tumor suppressor genes associated with cholangiocarcinoma. Methods The genomic imbalances of 18 cases of cholangiocarcinoma were analyzed by comparative genomic hybridization, ie, amplification and loss of DNA copy number. Results The common chromosomal DNA amplification regions of cholangiocarcinoma were 8q, 20q, 5p and 17q. The regions of chromosomal DNA deletions were 3p, 18q, 17p, 8p and 9p. Conclusion There are many copies of chromosomes in cholangiocarcinoma. The 3p, 5p, 8p, 8q, 9p, 17p, 17q, 18q and 20q sites may have oncogenes and tumor suppressor genes closely associated with cholangiocarcinoma.