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目的:探索美常安联合柳氮磺吡啶治疗溃疡性结肠炎(UC)的疗效,及对血清TNF-α、IL-6、IL-8水平的影响。方法:选择自2012年9月至2014年12月我院收治的100例UC患者,按照随机数表法分成对照组和观察组,每组50例。对照组患者口服给予柳氮磺吡啶,观察组患者口服给予美常安联合柳氮磺吡啶治疗。统计分析两组患者的临床有效率、症状改善、不良反应发生情况及治疗前后患者血清中TNF-α、IL-6、IL-8水平的变化。结果:观察组中总有效率为92.00%显著高于对照组中总有效率为48.00%(P<0.05);两组患者治疗后的主要临床症状较治疗前均有明显改善(P<0.05),且观察组患者治疗后主要症状缓解率明显高于对照组(P<0.05);两组患者治疗后血清中TNF-α、IL-6、IL-8水平均显著低于治疗前,且观察组明显低于对照组(P<0.05);两组患者不良反应发生率之间的差异无统计学意义(P>0.05)。结论:美常安联合柳氮磺吡啶治疗UC具有良好的临床疗效,能显著改善患者的临床症状和患者血清中炎症因子的水平,值得在临床上推广使用。
Objective: To explore the curative effect of Mei Changan combined with sulfasalazine on the treatment of ulcerative colitis (UC) and its effect on serum TNF-α, IL-6 and IL-8 levels. Methods: From September 2012 to December 2014, 100 cases of UC patients admitted to our hospital were divided into control group and observation group according to the random number table method, with 50 cases in each group. Patients in the control group were treated with sulfasalazine orally, and patients in the observation group were orally given metoclopramide combined with sulfasalazine. The clinical efficacy, symptom improvement, adverse reactions and changes of serum TNF-α, IL-6 and IL-8 levels in patients before and after treatment were statistically analyzed. Results: The total effective rate in the observation group was 92.00%, which was significantly higher than that in the control group (48.00%, P <0.05). The main clinical symptoms after treatment in both groups were significantly improved (P <0.05) , And the remission rate of the main symptoms after treatment in the observation group was significantly higher than that in the control group (P <0.05). The levels of TNF-α, IL-6 and IL-8 in the two groups were significantly lower than those before treatment Group was significantly lower than the control group (P <0.05). There was no significant difference between the two groups in the incidence of adverse reactions (P> 0.05). CONCLUSION: The combination of PCA and sulfasalazine has a good clinical curative effect, which can significantly improve the clinical symptoms and serum levels of inflammatory cytokines in patients, and is worth popularizing in clinic.