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扑热息痛经常与苯海拉明合用。作者应用高压液相层析法测定了家兔给药前后血液中扑热息痛的量,及兔胃排空速率,阐明了口服给扑热息痛及苯海拉明的交互作用机制,证明苯海拉明引起胃排空的延迟,影响扑热息痛的吸收速率,但不影响其吸收程度。取新西兰雄性白兔体重2.8～3.5kg,实验前禁食38～42小时,不禁水,实验时禁食并禁水。扑热息痛100mg/kg单独使用或与苯海拉明10、20mg/kg合并使用。将药物溶于70ml35～37°去离子水中,口服给药。在服药前及服药后0.25,0.5,0.75,1.0,1.5,2,3,4,5,6小时,从耳静脉取血样0.5ml(肝素抗凝),离心,
Paracetamol is often used in combination with diphenhydramine. The authors applied HPLC to determine the amount of paracetamol in the blood and the rate of gastric emptying in rabbits before and after administration. The interaction mechanism between oral paracetamol and diphenhydramine was elucidated. Diphenhydramine-induced gastric The delay in emptying affects the absorption rate of paracetamol but does not affect its absorption. Take New Zealand white rabbits weighing 2.8 ~ 3.5kg, fasting before the experiment 38 to 42 hours, can not help but water, fasting and no water in the experiment. Paracetamol 100mg / kg alone or with diphenhydramine 10, 20mg / kg combined use. The drug was dissolved in 70ml35 ~ 37 ° deionized water, oral administration. Before taking the drug and taking 0.25, 0.5, 0.75, 1.0, 1.5, 2, 3, 4, 5 and 6 hours, the blood sample was taken from the ear vein 0.5ml (heparin anticoagulation)