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目前大量流行病学和实验室研究表明非甾体抗炎药物(N SA ID s)能抑制甚至逆转大肠癌癌前病变[1]。其主要机制可能与N SA ID s抑制环氧化酶-2(Cyclooxygenase-2,COX-2)合成前列腺素(PG)有关,另外促凋亡和抗氧化也起一定作用。选择性COX-2抑制剂和一氧化氮释放性非甾体抗炎药(NO-
At present a large number of epidemiological and laboratory studies have shown that non-steroidal anti-inflammatory drugs (N SA ID s) can inhibit or even reverse the precancerous lesions of colorectal cancer [1]. Its main mechanism may be related to the inhibition of NACIDs by cyclooxygenase-2 (COX-2) synthesis of prostaglandins (PG), in addition to promote apoptosis and antioxidation also play a role. Selective COX-2 inhibitors and nitric oxide-releasing non-steroidal anti-inflammatory drugs (NO-