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转化生长因子 β1 可刺激系膜细胞外基质 (ECM)蛋白的合成 ,抑制基质金属蛋白酶的酶解活性 ,并增加其抑制剂组织型金属蛋白酶抑制剂的活性 ,从而促进ECM的沉积 ,在糖尿病肾病的发生发展中具有重要作用
Transforming growth factor β1 stimulates the synthesis of mesangial extracellular matrix (ECM) protein, inhibits the enzymatic activity of matrix metalloproteinases and increases the activity of inhibitors of tissue inhibitor of metalloproteinase (TIMP), thereby promoting the deposition of ECM. In diabetic nephropathy The occurrence and development of an important role