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业已证明,在人群中吸烟者支气管肺癌的发生率比非吸烟者约高10倍;既有石棉的职业接触又吸烟者,则肺癌发生率比一般人群高80～90倍。然而,迄今对吸烟与接触石棉的协同致癌作用之生物学基础尚未得到阐明。本文旨在观察这种物理性的(石棉)与化学性的(苯并芘)致癌物是如何引起上皮细胞化生(metaplasia)与促进~3H-胸腺嘧啶核苷摄取而起着协同致癌作用的。
It has been demonstrated that the incidence of bronchial lung cancer in smokers is about 10 times higher than that of non-smokers; in occupational exposure to both asbestos and smokers, the incidence of lung cancer is 80 to 90 times higher than that in the general population. However, the biological basis of the synergistic carcinogenic effects of smoking and exposure to asbestos has not yet been elucidated. The purpose of this paper is to observe how this physical (asbestos) and chemical (benzoquinone) carcinogen causes synergistic carcinogenesis due to epithelial metaplasia and promotion of ~3H-thymidine uptake. .