目的评估内镜下硬化疗法与套扎术对食管静脉曲张出血的急症止血及血管闭塞的效果．方法采用Ｇｉｓ８型胃镜、美国ＢＡＲＤ公司的连续结扎器及天津医科大学生产的单个结扎器，对肝硬变食管静脉曲张患者１００６例行硬化剂疗法或套扎术，并随访３个月～１１年观察其疗效．结果单纯硬化剂组（ｎ＝８７９）急症止血成功率９４６％，血管闭塞率４０２％，再出血率１１２％，并发症１０５％；而单纯套扎组（ｎ＝６１）分别为：９３８％，６５６％，１６％和４９％；套扎＋硬化组（ｎ＝６６）分别为：９６２％，９０９％，１５％及６１％．结论套扎＋硬化疗法优于单纯硬化和单纯套扎术． Objective To evaluate the effect of endoscopic sclerotherapy and ligation on emergency hemostasis and vascular occlusion of esophageal variceal bleeding. Methods A total of 1006 patients with cirrhosis esophageal varices were treated with sclerotherapy or ligation with Gis8 gastroscope, continuous ligation by BARD Company of the United States and single ligation produced by Tianjin Medical University. All patients were followed up for 3 months ~ 11 years to observe its efficacy. Results In the simple sclerosant group (n = 879), the successful rate of hemostasis was 94.6%, the rate of vascular occlusion was 402%, the rate of rebleeding was 112% and the complication rate was 105% 61) were 938%, 656%, 16% and 49% respectively. Ligation + sclerotherapy group (n = 66) were 962%, 909%, 1 5% and 6  1%. Conclusion Ligation + sclerotherapy is better than simple sclerotherapy and simple ligation.