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甘露醇常用于降低颅内压,但它在脑外伤的长期使用价值尚有争论。作者在24例严重脑外伤病人,观察一次静脉注射甘露醇0.5 g/kg 对颅内压、脑灌注压和脑血流的影响。脑血流是通过使用甘露醇前和10～20分钟后~(133)氙静脉注射法算得的。甘露醇注射可明显增加脑血流17.2%(由47.6±4.4 ml/100 g/min 上升至55.8±4.8 ml/100 g/min),同时使脑灌注压升高和颅内压降低。
Mannitol is often used to reduce intracranial pressure, but its long-term use in brain trauma is controversial. In 24 patients with severe traumatic brain injury, the authors observed an intravenous injection of mannitol 0.5 g / kg on intracranial pressure, cerebral perfusion pressure and cerebral blood flow. Cerebral blood flow was calculated before and after intravenous administration of ~ (133) xenon using mannitol 10 to 20 minutes later. Mannitol injection significantly increased cerebral blood flow by 17.2% (from 47.6 ± 4.4 ml / 100 g / min to 55.8 ± 4.8 ml / 100 g / min) while increasing cerebral perfusion pressure and intracranial pressure.