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目的:探讨支原体肺炎(MPP)患儿细胞及体液免疫状况,为临床及时有效地对MPP患儿免疫治疗提供理论依据。方法:将140例肺炎患儿分为支原体肺炎组80例、细菌性肺炎组60例,选取同期门诊体检正常小儿42例作为正常对照组,采用流式细胞术和免疫透射比浊法分别检测三组儿童的T细胞亚群、免疫球蛋白IgG、IgA、IgM及补体C3、C4。结果:CD3+、CD4+、CD4+/CD8+比值及补体C3明显低于正常对照组(P<0.01),免疫球蛋白IgG、IgA、IgM、补体C4及CD8+与正常对照组相比,差别无统计学意义(P>0.05)。结论:MPP患儿T淋巴细胞亚群功能失调,细胞免疫功能处于明显低下状态,而免疫球蛋白水平与正常对照儿童比较差别无统计学意义,在常规治疗同时,使用调节机体细胞免疫功能的药物,提高患儿机体细胞免疫功能对MPP的防治具有重要的临床意义。
Objective: To investigate the cellular and humoral immune status in children with Mycoplasma pneumonia (MPP) and to provide a theoretical basis for the immunotherapy of MPP children in a timely and effective manner. Methods: One hundred and forty cases of children with pneumonia were divided into 80 cases of mycoplasma pneumonia group and 60 cases of bacterial pneumonia group. Forty-two healthy children were selected as the normal control group. Flow cytometry and immunoturbidimetry were used to detect three T-cell subsets of children, immunoglobulin IgG, IgA, IgM and complement C3, C4. Results: The ratios of CD3 +, CD4 +, CD4 + / CD8 + and C3 were significantly lower than those in the normal control group (P <0.01). Immunoglobulin IgG, IgA, IgM, complement C4 and CD8 + were not significantly different from the normal control group (P> 0.05). Conclusion: The T lymphocyte subsets in children with MPP are dysfunctional and the cellular immune function is in a significantly low state. There is no significant difference in the immunoglobulin levels between the children with normal controls and the routine treatment. , To improve the cellular immune function in children on the prevention and treatment of MPP has important clinical significance.