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本文应用比色法和酶联免疫吸附法检测了48例酒精性肝病三个不同时期(酒精性脂肪肝、酒精性肝炎和酒精性肝硬化)患者血清中NO、TNF-α、IL-6的浓度。结果显示:酒精性脂肪肝和酒精性肝炎患者血清TNF-α、IL-6浓度均高于正常对照组(P<0.01)。提示:NO、TNF-α及IL-6在酒精性肝病从酒精性脂肪肝酒精性肝炎酒精性肝硬化的发展过程中起一定的作用,联合检测对判断酒精性肝病病程及预后有一定的指导意义。
In this paper, the serum levels of NO, TNF-α and IL-6 in 48 patients with alcoholic liver disease (alcoholic fatty liver, alcoholic hepatitis and alcoholic cirrhosis) were measured by colorimetric and enzyme-linked immunosorbent assay concentration. The results showed that the levels of serum TNF-α and IL-6 in patients with alcoholic fatty liver and alcoholic hepatitis were higher than those in normal control group (P <0.01). It is suggested that NO, TNF-α and IL-6 play a role in the development of alcoholic liver disease from Alcoholic Fatty Liver Alcoholic Hepatitis Alcoholic Liver Cirrhosis. The combined test can guide the judgment of the course and prognosis of alcoholic liver disease significance.