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目的分析2011年1月-2011年11月保定地区新生儿先天性甲状腺功能减低症(CH)的发病特点。方法对此时间段内由市,各区,县医疗保健单位送往保定市新生儿疾病筛查中心的新生儿足跟血滤纸干血片100 749人份,(生后3-7天采血,滴于S&903S型滤纸上)采用时间分辨荧光免疫技术,检测干血斑中促甲状腺素(hTSH)含量,将复查可疑阳性患儿召回,通过血清学甲功五项检测(电化学发光法)进行确诊。结果 100 749人新生儿中,筛查出可疑阳性患儿1856人,男998人,女858人,筛查阳性率1.84%,召回1548人,召回率83.4%,确诊CH患儿42人,男21人,女21人,检出率约1/2399,与2008年报道的检出率1/3333相比有所上升。其中1月发病率最低,4月最高,1月～4月呈上升趋势,6、9、11月发病较低,其余月较高。结论新生儿筛查是早期发现先天性甲状腺功能减低症患儿的重要手段,2011年1月～11月期间,CH发病率比以往高,9月～11月是筛查高峰期,但不是发病高峰期,1月～4月发病率呈上升趋势,其余月无规律。
Objective To analyze the incidence of neonatal congenital hypothyroidism (CH) in Baoding from January 2011 to November 2011. Methods During this period, 100 749 newborn hematopharmacological dry blood films from neonates sent to Baoding Neonatal Disease Screening Center by city, district and county health care units were collected. Blood samples were taken from 3-7 days after birth On the S & 903S filter paper) using time-resolved fluorescence immunoassay, dried blood spots in the detection of thyroid-stimulating hormone (hTSH) content, will review the suspicious positive children were recalled by serological methylation five tests (electrochemiluminescence) were diagnosed . Results Among 100 749 newborns, 1856 suspicious positive children were screened, 998 were male and 858 were female, the positive rate of screening was 1.84%, 1548 were recalled, the recall rate was 83.4%, and 42 children with CH were diagnosed as male 21 people and 21 women, the detection rate of about 1/2399, and the 2008 report of the detection rate of 1/3333 compared to an increase. Among them, the morbidity was the lowest in January, the highest in April, the upward trend in January to April, the low incidence in June, September and November and the high in the remaining months. Conclusion Neonatal screening is an important means to detect congenital hypothyroidism in early stage. From January to November, 2011, the incidence of CH was higher than before, and the peak of screening was from September to November, but it was not the incidence The peak period, January to April the incidence was on the rise, the rest of the month without law.