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目的:研究Turner综合征(TS)患儿的子宫、卵巢的发育及其功能状况。方法:对22例年龄为4.8~16.8岁的TS患儿(染色体核型为45,XO者11例,其他核型11例),超声测量并记录子宫、卵巢的各径,并检测患儿血清促性腺激素(FSH、LH)和雌二醇(E2)。结果:22例患儿中超声检查无子宫者4例,无卵巢者18例,患儿的子宫和卵巢各径及体积明显低于正常对照组(P<0.05),患儿组血清FSH、LH水平高于对照组(P<0.05),E2水平低于对照组(P<0.05)。患儿的染色体核型及卵巢的有无对患儿的子宫和/或卵巢的发育及血清FSH、LH和E2的水平有一定的影响。结论:多数TS患儿存在着卵巢、子宫发育不全甚至退化萎缩,并伴有血清性激素水平的异常。盆腔超声和血清性激素检测能较好地反映出TS患儿的子宫、卵巢形态及功能状态。
Objective: To study the development and function of uterus and ovary in children with Turner syndrome (TS). Methods: Twenty-two children with TS ranging from 4.8 to 16.8 years old (45 karyotype, 11 XO and 11 other karyotypes) were enrolled in this study. The uterus and ovary diameters were measured by ultrasound and the serums of children Gonadotropin (FSH, LH) and estradiol (E2). Results: There were 4 cases of uterus without ultrasound and 18 cases without ovary in 22 cases of children. The diameter and volume of uterus and ovary in children were significantly lower than those in normal control group (P <0.05). Serum FSH, LH The level of E2 was lower than that of the control group (P <0.05), and the level of E2 was lower than that of the control group (P <0.05). Children with karyotype and ovarian presence or absence of children with uterine and / or ovarian development and serum FSH, LH and E2 levels have a certain impact. Conclusion: Most TS patients have ovarian, uterine hypoplasia or even degenerative atrophy, accompanied by abnormal serum levels of sex hormones. Pelvic ultrasound and serum sex hormone test can better reflect the TS in children with uterine and ovarian morphology and functional status.