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阿斯匹林可能是世界上应用最广泛的药物,常与其他药物合用,因此要考虑阿斯匹林对其它药物的药代动力学和有效性的影响,已知阿斯匹林可干扰一些药物的生物转化或在血浆蛋白的一些特殊结合部位取代其他药物。炔诺酮是多种OC和皮下埋植剂中的主要成份,阿斯匹林常与炔诺酮同时使用,已知家兔是研究药物或营养因素对炔诺酮药代动力学影响的合适的动物模型。作者在本文中报告
Aspirin is probably the most widely used drug in the world and is often used in combination with other medications. Therefore, considering the impact of aspirin on the pharmacokinetics and effectiveness of other medications, aspirin is known to interfere with some Biotransformation of drugs or substitution of other drugs in some special binding sites of plasma proteins. Norethisterone is a major component of many OCs and subcutaneous implants. Aspirin is often used in combination with norethindrone. Rabbits are known to be suitable for studying the pharmacokinetics of drugs and / or norethindrone Animal model. The author reports in this article