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探讨急性心肌梗塞早期血浆内皮素（ＥＴ）与心肌梗塞并发症、肌酸磷酸激酶（ＣＰＫ）和左室射血分数的关系。应用放射免疫技术观察３６例急性心肌梗塞患者（无并发症者２２例为Ⅰ组，有并发症者１４例为Ⅱ组）发病后７２小时内血浆ＥＴ浓度变化，并选择２２例健康志愿者作为对照。结果表明：Ⅰ组在发病后ＥＴ浓度升高很快，６小时内达峰值为５２．０８±４．３４ｎｇ／Ｌ（Ｐ＜０．０５），但２４小时内很快下降至正常水平；Ⅱ组浓度升高更快，６小时峰值为６９．１２±５．８６ｎｇ／Ｌ（Ｐ＜０．０５），并持续到７２小时仍维持较高水平；ＥＴ与ＣＰＫ之间无明显相关性，且后者的峰值较晚；Ⅱ组ＥＴ与左室射血分数之间则呈负相关（Ｐ＜０．０５）。提示，急性心肌梗塞早期血浆ＥＴ素明显增高，对心肌血供及心脏功能有着很大的影响。
To investigate the relationship between early plasma endothelin (ET) and myocardial infarction complications, creatine phosphokinase (CPK) and left ventricular ejection fraction in acute myocardial infarction. Radioimmunoassay was used to observe the changes of plasma ET levels in 36 patients with acute myocardial infarction (22 patients without complications, group Ⅰ, 14 patients with complications) within 72 hours after onset, and 22 healthy volunteers Control. The results showed that the concentration of ET in group Ⅰ increased rapidly after onset, reached the peak value of 52.08 ± 4.34ng / L in 6 hours (P <0.05), but decreased to normal level in 24 hours (P <0.05), and maintained a high level for 72 hours. No significant correlation was found between ET and CPK, and the peak value at 6 hours was 69.12 ± 5.86 ng / L The latter peak was late; ET between ET and left ventricular ejection fraction was negatively correlated (P <0.05). Tip, early acute myocardial infarction significantly increased serum ET, myocardial blood supply and cardiac function has a great impact.