传统的免疫学认为机体受外界抗原(简称“非己的”)刺激后,则发生免疫应答;反之,对自身器官、组织、细胞、蛋白等(简称“自己的”)也起免疫应答则是不可想象的。五十年代作动物的皮肤移植试验,发现非己的皮肤在一定的条件下,也能成为“自己的”,不起免疫应答。这就考虑到无或低免疫应答的问题,也就是广义的免疫耐 Traditional immunology believes that the immune response occurs when the body is stimulated by external antigens (“non-self”); on the contrary, the immune response to its own organs, tissues, cells, proteins, etc. unimaginable. Fifties for animal skin transplant test found that non-skin under certain conditions, can also be “own”, can not afford immune response. This takes into account the problem of no or low immune response, that is, broad immune tolerance