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目的:Lambert-Eaton(LEMS)肌无力综合征临床上少见。本报道旨在增进人们对这一综合征的认识。方法:对LEMS10例病人的临床资料做回顾性分析。结果:全组男9例,女1例,发病年龄43~69岁。首发症状以双下肢无力最常见(80%)。随访期间有颅神经受累(50%)、下肢无力(100%)、上肢无力(70%)、植物神经症状(50%)、腱反射减低(80%)。组织学检查9例为小细胞肺癌(SCLC),1例肺癌分型不详。肌无力症状早于肺部症状平均5.1月。抗肿瘤治疗7例,有4例LCMS完全消失,1例好转。结论:提示LEMS与SCLC有高亲和性。对40岁以上男性LEMS病人应积极寻找恶性肿瘤的存在,尤其是SCLC。
Purpose: Lambert-Eaton (LEMS) myasthenia syndrome is rare in clinical practice. This report aims to increase people’s awareness of this syndrome. Methods: A retrospective analysis was performed on the clinical data of 10 LEMS patients. Results: There were 9 males and 1 female in the whole group. The age of onset was 43 to 69 years old. The first symptoms are most common with lower limb weakness (80%). During follow-up, there were cranial nerve involvement (50%), lower limb weakness (100%), upper limb weakness (70%), autonomic symptoms (50%), and reduced tendon reflexes (80%). Histological examination of 9 cases of small cell lung cancer (SCLC), 1 case of lung cancer is unknown. Symptoms of muscle weakness preceded pulmonary symptoms by an average of 5.1 months. Anti-tumor therapy in 7 cases, 4 cases of LCMS completely disappeared, 1 case improved. Conclusion: It is suggested that LEMS has high affinity with SCLC. LEMS patients over 40 years of age should actively look for the presence of malignant tumors, especially SCLC.