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目的探讨乳腺浸润性微乳头状癌(invasive micropapillary carcinoma,IMPC)临床病理特征。方法分析13例IMPC患者(IMPC组)临床资料,检测雌激素受体、孕激素受体、人类表皮生长因子受体-2、抗原Ki-67等水平,并与同期26例乳腺浸润性导管癌患者(对照组)进行比较。结果 IMPC组淋巴结转移率(92.31%)、pTNM分期Ⅲ期以上比率(61.54%)高于对照组(46.15%、26.92%)(P<0.05);2组雌激素受体、孕激素受体、人类表皮生长因子受体-2、抗原Ki-67阳性表达率比较差异均无统计学意义(P>0.05)。结论 IMPC具有高淋巴结转移、高侵袭性等特征。
Objective To investigate the clinicopathological features of invasive micropapillary carcinoma (IMPC). Methods The clinical data of 13 patients with IMPC (IMPC group) were analyzed to detect the levels of estrogen receptor, progesterone receptor, human epidermal growth factor receptor-2, and antigen Ki-67, and compared with 26 cases of breast invasive ductal carcinoma in the same period. Patients (control group) were compared. Results The lymph node metastasis rate in IMPC group (92.31%) and the rate of pTNM stage III (61.54%) were higher than those in the control group (46.15%, 26.92%) (P<0.05); estrogen and progesterone receptors in group 2; There was no significant difference in the positive expression rates of human epidermal growth factor receptor-2 and antigen Ki-67 (P>0.05). Conclusion IMPC has high lymph node metastasis and high invasiveness.