患者男,44岁,木工,因右小腿反复流脓,肿痛37年,皮肤疣状增生17年,橡皮肿样外观8年于1988年4月11住院.自幼年发病,8岁开始先在右小腿胫前发现多个黄豆大的脓疱,破溃后糜烂渗水不止,由于脓液渗出物刺激,溃烂面不断扩大.曾经消炎服用中草药等治疗,一度病损缩小,疼痛减轻,但皮损时轻时重经久不愈,遍及整个小腿,形成大片疤痕,足跟至足背周围形成疣状皮损,拟诊“泛发性寻常疣”,于1982年、1983年、1985年先后3次作外科整形手术.但每次手术后数月,又在原处长出新赘生物,伴有脓性分泌物,由于多次切割结疤,局部血供及回流均有不同程度障碍,导致患肢肿胀,着地疼痛、不能站立、终成橡皮腿样外观,来我科门诊以“着色真菌病”收治.体检:心肺腹部检查均在正常范围,皮肤科检查右小腿肿胀,压之坚实无凹陷,皮肤表面见色素沉着与色素减退相间,足底可见数处呈圆形、椭圆形及不规则形的褐色赘生物,呈角刺状 Male, 44 years old, carpenter, repeated pus in the right lower leg, swelling and pain for 37 years, 17 cases of verrucous hyperplasia of the skin, appearance of the edema in 8 years in April 1988 11 hospitalized. In the right lower leg anterior tibia found that more than a large pustules, ulceration erosion after erosion more than, due to stimulation of pus exudate, ulcers continue to expand .Anti-inflammatory anti-inflammatory herbs such as treatment, once the lesion shrinks, reduce pain, but Lesions when the light weight of prolonged unhealed, throughout the lower leg, the formation of large scars, heel to the foot back around the formation of verrucous lesions, the proposed “common vulvar warts” in 1982, 1983, 1985 has 3 times for surgical plastic surgery.But a few months after each operation, but also grow new neoplasms in place, accompanied by purulent secretions, due to multiple cutting scarring, local blood supply and return have varying degrees of obstacles, resulting in Limb swelling, pain in the ground, can not stand, and finally become rubber leg-like appearance, to our clinic with “colored fungal disease” admitted. Physical examination: cardiopulmonary abdominal examination are in the normal range, dermatology check right leg swelling, Depression, see the skin surface pigmentation and hypochromic phase, the bottom of the plant can be seen a few round , Oval and irregularly shaped brown neoplasm, shaped as a Chaetoceros