在动物和人体内,许多药物在肝脏内发生化学变化。这些化学变化主要是由于细胞微粒体的光面内质网(或光面膜)内的酶的作用。因此,药物的作用强度、作用持续时间和毒性,在很大程度上取决于药物的代谢速度,而药物代谢速度又决定于微粒体酶的活性。在许多因素的影响下, In animals and humans, many drugs undergo chemical changes in the liver. These chemical changes are mainly due to the action of enzymes within the luminal endoplasmic reticulum (or light mask) of the cellular microsomes. Therefore, the strength of the drug’s action, duration of action and toxicity depend largely on the rate of drug metabolism, which in turn depends on the activity of the microsomal enzyme. Under the influence of many factors,