目的　探讨对中晚期胰头癌积极进行外科切除治疗的价值及肿瘤的性状与生存的关系。　方法　用回顾性方法研究 1970～ 2 0 0 0年收治的胰腺癌行根治性胰十二指肠切除术的相关因素 ,42 1例行手术治疗的胰腺癌患者 ,其中 96例行Whipple手术或区域性胰十二指肠切除术。　结果　 70年代、80年代和 90年代胰头癌的切除率分别为 9 5 %、16 6 %和 2 8 2 %。 90年代后期采用三阶段法 (减黄 介入 手术 ) ,使手术切除率进一步提高 ,达 37 1%。三个年代的 1年的生存率分别为5 0 %、5 7 1%和 6 1 6 % ,3年生存率分别为 2 5 %、 2 8 5 %和 2 7 7% ,5年生存率分别为 0、 9 5 %和11 1%。胰头癌患者的长期生存与肿瘤的大小、淋巴结转移和神经丛的浸润有关。　结论　对中晚期胰头癌积极进行手术治疗 ,能改善患者生活质量 Objective To explore the value of aggressive surgical resection of advanced pancreatic head cancer and the relationship between tumor traits and survival. Methods A retrospective study of factors associated with radical pancreatoduodenectomy for pancreatic cancer treated in 1970-2000 and 42 patients undergoing surgical treatment for pancreatic cancer were performed. Of these patients, 96 were treated with Whipple surgery or regional Pancreatoduodenectomy. Results The resection rates of pancreatic cancer in the 1970s, 1980s and 1990s were 95%, 166% and 282%, respectively. In the late 1990s, a three-stage procedure (yellow-involved interventional surgery) was used to further increase the surgical resection rate to 37.1%. The three-year survival rates for the three years were 50%, 57.1%, and 61.6%, respectively. The 3-year survival rates were 25%, 28.5%, and 27.77%. The 5-year survival rates were It is 0, 95%, and 11 1%. The long-term survival of patients with pancreatic head cancer is related to tumor size, lymph node metastasis, and infiltration of nerve plexus. Conclusion Actively treating advanced stage pancreatic head cancer can improve the quality of life of patients