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目的探讨乙肝肝硬化患者抗病毒治疗前后血浆中D-二聚体的水平变化及分子机制研究。方法选取2010年5月—2013年8月来该院治疗乙肝肝硬化的患者共70例,搜集患者的一般资料及临床信息,按照随机分组的原则,将患者分成对照组和观察组,每组各35例,分别采取常规药物治疗和抗病毒治疗,观察治疗前后血浆中D-二聚体的水平变化。结果与对照组相比,乙肝肝硬化患者在进行核苷(酸)类似物抗病毒治疗后,血浆内D-二聚体水平的下降程度明显,二组比较差异有统计学意义。在对Child B级与C级患者的研究过程中,治疗前血浆D-二聚体水平差异具有统计学意义,在进行抗病毒治疗后,Child B患者和Child C患者的二聚体水平明显下降,到9个月后两者的比较P>0.05,差异无统计学意义。结论抗病毒药物不仅可以抑制病毒复制,还能够降低血浆中的D-二聚体水平(降低)。
Objective To investigate the plasma levels of D-dimer and its molecular mechanisms before and after antiviral therapy in patients with hepatitis B cirrhosis. Methods A total of 70 patients with cirrhosis of liver cirrhosis from May 2010 to August 2013 were selected to collect general information and clinical information of patients. According to the principle of randomization, patients were divided into control group and observation group. Each group Each 35 patients were treated with conventional drugs and antiviral therapy to observe changes in plasma levels of D-dimer before and after treatment. Results Compared with the control group, the level of D-dimer in plasma was significantly decreased in patients with hepatitis B cirrhosis after antiviral treatment with nucleos (s) analogues. The difference between the two groups was statistically significant. In the study of Child B and C patients, the difference in plasma D-dimer level before treatment was statistically significant. After antiviral treatment, the dimer levels in Child B and Child C patients decreased significantly , After 9 months the comparison between the two P> 0.05, the difference was not statistically significant. Conclusion Antiviral drugs not only inhibit viral replication, but also decrease (decrease) D-dimer levels in plasma.