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在培养的 Lewis 肺癌组织块和 A_(549)肺癌细胞系细胞培养液中加入微量元素锌、锰和硒,24小后测定各组的 SOD 活性发现:锌、锰明显地提高了癌组织和癌细胞的 SOD 活性.这种作用可能与增加了 SOD 的必需成分而使细胞内不具活性的 SOD 的酶蛋白被激活而转变为有活性的 SOD 有关.结果提示:锌、锰的抑癌作用有可能是通过 SOD 的作用实现的。
Adding trace element zinc, manganese and selenium to cultured Lewis lung carcinoma cell line and A54g lung cancer cell line, 24 hours later, the activity of SOD in each group was found: zinc and manganese obviously increased the cancer tissue and cancer Cell SOD activity.This effect may be related to the increase of the essential components of SOD so that the intracellular inactive SOD enzyme protein is activated and transformed into active SOD.The results suggest that: zinc, manganese tumor suppressor effect may Is achieved through the action of SOD.