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目的:建立桂枝茯苓胶囊中桂皮醛和丹皮酚的含量测定方法。方法:以XTerra RP_(18)色谱柱为分离柱,以甲醇-水(60:40)为流动相,采用SPE-HPLC法测定。结果:本品中桂皮醛含量测定线性范围为19.72~157.76μg·ml~(-1)(r=0.999 9),平均回收率为97.60%(RSD=1.13%,n=6);丹皮酚含量测定线性范围为151.4~757.0μg·ml~(-1)(r=0.999 9),平均回收率为97.80%(RSD=1.53%,n=6)。结论:此法操作简单、结果准确,可用于桂枝茯苓胶囊的质量控制。
Objective: To establish a method for the determination of cinnamic aldehyde and paeonol in Guizhi Fuling capsule. Methods: The separation was performed on a XTerra RP_ (18) column with methanol-water (60:40) as the mobile phase and determined by SPE-HPLC. Results: The linear range of cinnamic aldehyde was 19.72 ~ 157.76μg · ml ~ (-1) (r = 0.999 9), the average recovery was 97.60% (RSD = 1.13%, n = 6) The linear range was 151.4-757.0 μg · ml -1 (r = 0.999 9). The average recovery was 97.80% (RSD = 1.53%, n = 6). Conclusion: This method is simple, accurate and can be used to control the quality of Guizhi Fuling capsules.