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本文应用单克隆抗体(Mcab)MG7及CA50分别对18例胃癌及5例结肠癌进行了放射免疫导向手术(RIGS)的可行性研究。将41.07～61.42mBq/490～510μg的~(125)I及~(131)I标记的McAb MG7于术前3～9d经静脉输入18例胃癌患者(~(125)I组8例、~(131)I组10例).将72.15～84.18mBq/650μg的~(125)I标记的McAb CA50于术前4～10d经静脉输入5例结肠癌患者。术中用自制的手持式碘化钠丫探测仪(GDP)进行探测。结果18例胃癌13例探测阳性(72.5％)。5例结
The feasibility of radioimmunoguided surgery (RIGS) in 18 cases of gastric cancer and 5 cases of colon cancer was studied using monoclonal antibodies (Mcab) MG7 and CA50, respectively. 41.07～61.42mBq/490～510μg McAb MG7 labeled with ~(125)I and ~(131)I were intravenously input into 18 patients with gastric cancer (~(125)I group, 8 cases, ~( 131) In group I, 10 cases). Colon cancer patients were intravenously infused from 72.15 to 84.18 mBq/650 μg of 125 I-labeled McAb CA50 intravenously 4 to 10 days before surgery. An intraoperative hand-held sodium iodide detector (GDP) was used for intraoperative exploration. Results Eighteen cases of gastric cancer were positive (72.5%) in 13 cases. 5 cases