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前列腺癌是发生于男性前列腺组织中的恶性肿瘤,近年来我国前列腺癌发病率迅速上升.本文以前列腺癌细胞PC-3细胞株为主要研究对象,联合姜黄素类似物E10和多西紫杉醇作用于前列腺癌细胞,比较其与单独给药的作用效果.结果显示低剂量的姜黄素类似物E10与低剂量的多西紫杉醇联合使用,比两种药物单独高剂量使用更能有效地抑制前列腺癌细胞生长,核转录因子NF-κB信号传导通路和Erk1/2传导通路具有协同作用的机制.研究结果表明联合姜黄素类似物E10和多西紫杉醇对抑制前列腺癌细胞具有一定的协同效应.“,”Cancer of the prostate gland is a leading cause of death.In the present study,we studied the effects and mechanisms of curcumin analogue E10,docetaxel or their combination on prostate cancer (PC)-3 cells.Treatment of PC-3 cells with E10 or docetaxel resulted in growth inhibition in a concentration-reliant fashion.Combinations of E10 and docetaxel inhibited the growth of PC-3 cells in a synergistic manner.Effects of a combination of E10 and docetaxel were associated with synergistic inhibition of the transcriptional activity of nuclear factor-kappa B (NF-κB),and robust reductions in the levels of B-cell lymphoma-2 (Bcl-2) were found in PC-3 cells treated with a combination of E10 and docetaxel.Our data indicated that the effects of E10 in combination with docetaxel on PC-3 cells were associated with inhibition of NF-κB and Bcl-2.Further studies using suitable animal models are necessary to determine the in vivo effect of this combination.